Antibodies to stuctural proteins of endogenous retrovirus of the HERV-K/HTDV family as markers of human germ cell tumors
Seniuta, N.B.; Kleĭman, A.M.; Triakin, A.A.; Karseladze, A.I.; Shelepova, V.M.; Tiuliandin, S.A.; Gurtsevich, V.E.
Voprosy Virusologii 51(3): 17-21
2006
ISSN/ISBN: 0507-4088 PMID: 16826751 Document Number: 602025
Human germ cell tumors (GCT) have been found to be closely associated with the expression of HER,V-K/HTDV proviruses and most patients with GCT produce antibodies to the major HERV-K/HTDV Gag and Env proteins. The findings have shown a strong association of the level of HERV-K/HTDV antibodies with the clinical course of the disease and therapy success, which makes it possible to confirm the fact that viral protein antibodies may be used as an additional marker of GCT.