Hypersensitivity pneumonitis: experimental production in guinea pigs with antigens of Micropolyspora faeni
Wilkie, B.; Pauli, B.; Gygax, M.
Pathologia et Microbiologia 39(6): 393-411
1973
ISSN/ISBN: 0031-2959 PMID: 4271061 Document Number: 60202
Hypersensitivity pneumonitis produced in guinea-pigs by aerosol challenge with antigens of M. faeni after systemic immunization with soluble antigens of the organism emulsified in Freund's complete adjuvant. The condition was transferred to normal animals with plasma or washed lymphocytes from immunized animals. The lungs of affected animals had bronchopneumonia with an interstitial reaction including vasculitis of septal capillaries, proliferation of alveolar epithelial cells, parenchymal eosinophilia and neutrophilia. The pneumonitis was the result of both Arthus and delayed hypersensitivity reactions.