Standardization of coagulologic technique for antithrombin III estimation and its clinical application
Berkovskiĭ, A.L.; Sergeeva, E.V.; Kartoshkina, A.V.; Suvorov, A.V.
Klinicheskaia Laboratornaia Diagnostika 2006(8): 29-30
2006
ISSN/ISBN: 0869-2084 PMID: 17087244 Document Number: 601401
A standard assay procedure for estimating antithrombin III activity was derived from the Abildgaard technique as follows: 1) to decrease errors at the preanalytical stage, by using preliminarily defibrinated lyophilized plasma-calibrator and 2) to increase measurement accuracy, by using the concentration of a fibrinogen preparation and simplifying the analytical procedure. The estimation of plasma antithrombin activity in patients with pulmonary thromboembolism or sepsis points to the changes in antithrombin III activity.