Echinomycin production by Actinomadura sp. INA 654
Galatenko, O.A.; Terekhova, L.P.; Li, I.V.; Malkina, N.D.; Boĭkova, I.V.; Zenkova, V.A.; Katrukha, G.S.
Antibiotiki i Khimioterapiia 51(9-10): 3-7
2006
ISSN/ISBN: 0235-2990 PMID: 18030784 Document Number: 601023
An actinomycete strain designated as Actinomadura sp. INA 654 was isolated from a chernozem soil sample in the Voronezh Region by the soil sample treatment with millimetric waves (EHF band). The strain produced an antibiotic complex of 2 components, named A-654-I and A-654-II. Investigation of their physico-chemical properties showed that A-654-I was identical to echinomycin, a heteropeptide lactone of the quinoxaline group with antitumor activity, while A-654-II proved to be likely a new natural compound. Production of echinomycin by a representative of the Actinomadura genus was detected for the first time. Up to now, only representatives of the Streptomyces genus were known to produce echinomycin.