Interaction between venlafaxine and caffeine on antinociception in mice
Yaba, G.; Sezer, Z.; Tekol, Y.
Die Pharmazie 61(1): 60-62
2006
ISSN/ISBN: 0031-7144 PMID: 16454208 Document Number: 600872
This study was conducted to evaluate whether caffeine has any effect on venlafaxine antinociception in mice in acute application. Swiss albino mice, both male and female, were tested with hot plate analgesiameter set at 52.5+or-0.1 degrees C. 32 mice were equally divided into 4 groups and received saline + saline, caffeine (5 mg/kg) + saline, saline + venlafaxine (70 mg/kg) or caffeine (5 mg/kg) + venlafaxine (70 mg/kg) intraperitoneally. Each animal was tested on hot plate before treatment and at 30, 45 and 60 minutes after injections. Venlafaxine produced a significant antinociceptive effect at 30 and 45 minutes and the effect decreased at 60 minutes. Caffeine alone showed no significant antinociceptive effect at the applied dose; however, it significantly antagonized the antinociceptive effect of venlafaxine at 30 minutes. It is concluded that caffeine inhibits the antinociceptive effect of venlafaxine in acute application in mice, providing new evidence that the adenosinergic system may play a significant role in the mechanism of antinociceptive action of venlafaxine. This study raises the possibility that caffeine consumption might influence the effectiveness of venlafaxine in the treatment of pain in humans.