Signficance of tubulointerstitial lesions in kidney biopsy specimen of nephrotic patients in Iraq
Mansour, A.A.; Al-Shamma, I.
Medgenmed Medscape General Medicine 8(1): 8
2006
ISSN/ISBN: 1531-0132 PMID: 16915138 Document Number: 600317
Tubulointerstitial lesions (TIL) adversely affect the prognosis of various glomerulonephritis. The aim of this study is to evaluate the significance of TIL in the cortical area of renal biopsy specimens. A clinicopathologic prospective study was performed on patients with idiopathic nephrotic syndrome (NS). The presence of TIL was assessed qualitatively by light microscopic observation and was correlated with several histopathologic and clinical parameters at biopsy time, as well as with status at final follow-up. The total number of patients was 136 with a mean duration of follow-up of 23.8 -/+ 11.9 months. In all patients with idiopathic NS, the presence of TIL in the cortical area was correlated significantly with hypertension at presentation, response to treatment, and outcome. Histopathologically, TIL correlated with glomerular lesions. It was concluded that qualitative evaluation of TIL in the cortex could reflect glomerular injury and could contribute to the assessment of prognosis in patients with idiopathic NS.