Effective treatment of multifocal aggressive fibromatosis with low-dose chemotherapy
Caglar, K.; Ozyönüm, H.; Akalin, M.; Balci, S.
Turkish Journal of Pediatrics 48(4): 365-368
2006
ISSN/ISBN: 0041-4301 PMID: 17290575 Document Number: 600241
Desmoid tumor (aggressive fibromatosis), as a member of a group of borderline neoplasms, is a rare tumor of fibroblastic origin that remains difficult to treat. Treatments with surgery, radiotherapy and different medical protocols including interferon (IFN)-alpha, hormonal agents such as tamoxifen (anti-estrogen) as well as non-steroidal anti-inflammatory drugs and low-dose antineoplastic agents have been reported. In this report we describe a new patient with multifocal aggressive fibromatosis who was successfully treated with low-dose chemotherapy consisting of methotrexate and vinblastine.