Matrix metalloproteinase-2 and -9 expression in sinonasal inverted papilloma
Papon, J.F.; Lechapt-Zalcman, E.; Abina, M.; Abd-al-Sama, I.; Peynègre, R.; Escudier, E.; Coste, A.
Rhinology 44(3): 211-215
2006
ISSN/ISBN: 0300-0729 PMID: 17020070 Document Number: 599328
Statement of problem: Inverted papilloma (IP) is a proliferative lesion of the epithelium lining the sinonasal tract, characterized by marked propensity for recurrence and association with carcinoma. To determine a putative role of matrix metalloproteinase-2 (MMP-2) and MMP-9 in the establishment of IP, their expression was studied in IP.Methods: Archived surgical specimens from 15 IPs were studied using immunohistochemistry and compared to 12 nasal polyps (NP), a model of chronic respiratory mucosal inflammation, and to 6 control nasal mucosa (CM) samples obtained from snorers during turbinectomy. Within IP, MMP-2 and -9 expression was compared between tumoral areas with hyperplastic epithelium and non tumoral areas with nonhyperplastic epithelium.Results: In IP, MMP-2 and MMP-9 epithelial expression was not different compared to CM and NP. MMP-9 expression in submucosal inflammatory cells was not different between IP and CM or NP. However, within IP, a significantly increased number of MMP-9 positive inflammatory cells in the lamina propria adjacent to the hyperplastic epithelium was observed compared to the lamina propria adjacent to nonhyperplastic epithelium.Conclusion: Our findings suggest that MMP 9 expressing inflammatory cells may be involved in the pathophysiology of IP.