A non-invasive method of evaluation of Helicobacter pylori urease activity: its perfection and introduction to clinical practice
Tsodikov, G.V.; Ziakun, A.M.; Isakov, V.A.; Sudovtsov, V.E.; Matevosov, D.Iu.; Morozova, N.A.; Ganskaia, Z.Iu.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 2006(2): 35-41
2006
ISSN/ISBN: 0869-6047 PMID: 16544903 Document Number: 599208
The authors have developed a highly sensitive method of non-invasive diagnostics of Helicobacter pylori, the most frequent human infection. Detection of urease activity is based upon measurement of the degree of the elevation of stable C isotope content in exhaled air after administration of C-urea as a test reagent.The method has been scarcely applied in Russia because the test preparation, C urea had not been produced domestically until 2002.The method can be easily applied by any healthcare institution; however, it requires special equipment and trained personnel to perform measurement of C-13 content in exhaled air samples using mass spectrometers.The article presents the first experience in clinical application of the method.