Migraine and "sleep-wake" cycle
Osipova, V.V.; Levin, I.I.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 106(5): 9-15
2006
ISSN/ISBN: 1997-7298 PMID: 16768218 Document Number: 599016
The results of the comparative analysis of patients with migraine attacks developing in the waking period (AP) and night sleep period are presented. Patients with sleep-related migraine (SM) had higher levels of depression and anxiety, marked autonomic dysfunction and stable sleep disturbances that resulted in significant maladaptation of these patients in the between-attacks period and low quality of life. Depression plays a role in the transformation of AP to SM and formation of stable sleep disturbances in the between-attacks period in patients with SM. It is suggested that common serotoninergic mechanisms involved in migraine attack may contribute to formation of "sleep-wake" cycle and depression development. The principles of optimal therapy of such patients are formulated.