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The modulatory influence of moxonidine on the different link of sympatho-adrenal system and hemodynamic reactions in normo and hypertensive rats during emotional stress

Bakuridze, K.A.; Gongadze, N.V.

Georgian Medical News 133: 120-124

2006

ISSN/ISBN: 1512-0112
PMID: 16705249
Document Number: 598370
Effect of moxonidine on hemodynamic parameters, baroreflex sensitivity (BS) and sympatho-adrenal system was studied on the model of emotional stress in normotensive (N) and hypertensive (H) rats. Moxonidine was administered intravenously in daily dose 100 mcg/kg during one week prior to stress condition. It was shown that moxonidine reduced pressor reactions of arterial pressure, tachycardia and have increased BS especially in H animals, which was blunted during aversive stimulation. Moxonidine also revealed the effect of pharmacological correction of catecholamine - norepinephrine and epinephrine content in the myocardium and adrenals in stress and post stress period more markedly in H rats. The data obtained indicate the preventive antistress activity of the moxonidine.

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