The effect of gidazepam on the activity of the sympatho-adrenal system in operators working under the usual and complicated conditions
Morozov, I.S.; Barchukov, V.G.; Riabichenko, V.V.; Neznamov, G.G.; Zhirnov, E.N.
Eksperimental'naia i Klinicheskaia Farmakologiia 61(5): 6-9
1998
ISSN/ISBN: 0869-2092 PMID: 9854622 Document Number: 485375
In healthy volunteers a single dose (0.05 g) of hydazepam does not change, but in subjects with psychogenic stress-reactions one-week course of the drug (0.05 g/24 h) intensifies to optimum activation of the sympathoadrenal system in response to standard operator load, inducing prevalent excretion of norepinephrine but not of epinephrine in the urine and maintains a high level of dopamine and DOPA excretion. In operators working in a state of hypercapnia and hyperthermia a single dose of hydazepam (0.05 g) blocks stress activation of the sympathoadrenal system. In a state of hyperthermia hydazepam normalizes the blood histamine and serotonin content. In all cases hydazepam improves the condition of the operators and the quality of their work, which allows it to be considered an effective and safe agent for the correction of stress-induced disorders in operators.