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Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents

Chiosis, G.; Caldas Lopes, E.; Solit, D.

Current Opinion in Investigational Drugs 7(6): 534-541

2006

ISSN/ISBN: 1472-4472
PMID: 16784024
Document Number: 596837
Heat shock protein (Hsp)90 is a chaperone with essential roles in maintaining transformation and in elevating the survival and growth potential of cancer cells. The recognition of Hsp90 as an important target in cancer therapy has prompted the identification, development and clinical translation of a large array of Hsp90 inhibitors. This review discusses the modalities that may interfere with this chaperone's function and describes the status of existing and emerging Hsp90 inhibitor classes.

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Luo, H-ming.; Sun, W.; Yin, J-yuan.; Yang, X-hong. 2010: Progress in the study of heat shock protein 90 inhibitors Yao Xue Xue Bao 45(7): 813-820
Di, P.; Gao, Y. 2003: Studies of heat shock protein 60 and heat shock protein 70 in oral lichen planus Zhonghua Kou Qiang Yi Xue Za Zhi 38(4): 275-278
Schuppe; H.-Ch.; Pichlmeier; U.; Schenk; B. L; Böttcher; M 2003: Antibodies to Chlamydia trachomatis Heat Shock Protein (cHSP60) and Major Outer Membrane Protein (MOMP) in Men with Impaired Fertility Clinical Laboratory 49(5-6): 273-275
Targosz, A.; Pierzchalski, P.; Krawiec, A.; Szczyrk, U.; Brzozowski, T.; Konturek, S.J.; Pawlik, W.W. 2006: Helicobacter pylori inhibits expression of heat shock protein 70 (HSP70) in human epithelial cell line. Importance of Cag A protein Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society 57(2): 265-278
Li, W-jie.; Zhao, Z-jing.; Liu, B.; Zhang, D-xin.; Li, F.; Wang, H-chang.; Guo, W-yi.; Jia, G-liang.; Kitakaze, M.; Hori, M. 2008: Nitric oxide induces heat shock protein 72 production and delayed protection against myocardial ischemia in rabbits via activating protein kinase C Chinese Medical Journal 121(12): 1109-1113
Minohara, M. 2003: Heat shock protein 105 in multiple sclerosis Nihon Rinsho. Japanese Journal of Clinical Medicine 61(8): 1317-1322
Strik, H.M.; Weller, M.; Frank, B.; Hermisson, M.; Deininger, M.H.; Dichgans, J.; Meyermann, R. 2000: Heat shock protein expression in human gliomas Anticancer Research 20(6b): 4457-4462
Peibin, Y.; Shude, Y.; Changzhi, H. 2002: Heat shock protein gp96 and cancer immunotherapy Chinese Medical Sciences Journal 17(4): 251-256
He, B.; Li, Q.; Zhuo, H. 2013: Heat shock protein in male infertility: advances in studies Zhonghua Nan Ke Xue 19(5): 464-467
McKenzie, K.R.; Adams, E.; Britton, W.J.; Garsia, R.J.; Basten, A. 1991: Sequence and immunogenicity of the 70-kDa heat shock protein of Mycobacterium leprae Journal of Immunology 147(1): 312-319
Miyata, M.; Sato, H.; Sato, H.; Sato, Y.; Kodama, E.; Kasukawa, R. 1999: Significance of endogenous heat shock protein in adjuvant arthritis Journal of Rheumatology 26(10): 2210-2214
Geisler, J.P.; Manahan, K.J.; Geisler, H.E.; Tammela, J.E.; Rose, S.L.; Hiett, A.K.; Miller, G.A.; Wiemann, M.C.; Zhou, Z. 2004: Heat shock protein 27 in the placentas of women with and without severe preeclampsia Clinical and Experimental Obstetrics and Gynecology 31(1): 12-14
Udelsman, R.; Li, D.G.; Stagg, C.A.; Gordon, C.B.; Kvetnansky, R. 1994: Adrenergic regulation of adrenal and aortic heat shock protein Surgery 116(2): 177-182
Efferth, T.; Schulten, H.G.; Thelen, P.; Bode, M.E.; Beniers, A.J.; Granzen, B.; Ringert, R.H.; Mertens, R.; Gefeller, O.; Jakse, G.; Fuzesi, L. 2001: Differential expression of the heat shock protein 70 in the histological compartments of nephroblastomas Anticancer Research 21(4b): 2915-2920
2003: Heat shock protein protects beta cells. Is it possible soon to vaccinate against diabetes? MMW Fortschritte der Medizin 145(22): 53
Chen, W.; Shao, H.; Chi, M.; Zhang, Z.; Shan, Y.; Zou, W. 2015: Expression of heat shock protein 70 and its mRNA in career exposure to manganese Zhonghua Yu Fang Yi Xue Za Zhi 49(10): 914-918
Tanaka, T.; Suzuki, J.; Yamakawa, N.; Usui, M. 2000: Molecular biological analysis of retinal and streptococcal heat-shock protein 60 Nippon Ganka Gakkai Zasshi 104(5): 328-333
Wang, H-Hao.; Mao, C-Yu.; Teng, L-Song.; Cao, J. 2006: Recent advances in heat shock protein-based cancer vaccines Hepatobiliary and Pancreatic Diseases International: Hbpd Int 5(1): 22-27
Gryglewski, A.; Pajdak, W.; Witkowski, K. 1994: Clinical significance of heat shock proteins. Influence of heat shock proteins on the pathomechanism of selected diseases Przeglad Lekarski 51(7): 303-307
Ivarsson, K.; Myllymäki, L.; Jansner, K.; Bruun, A.; Stenram, U.; Tranberg, K-Göran. 2003: Heat shock protein 70 (HSP70) after laser thermotherapy of an adenocarcinoma transplanted into rat liver Anticancer Research 23(5a): 3703-3712