The effect of previous HBV infection on hepatocellular carcinoma with alcoholic liver disease
Tokushige, K.; Hashimoto, E.; Tobari, M.; Yatsuji, S.; Takakura, M.; Taniai, M.; Shiratori, K.
Nihon Arukoru Yakubutsu Igakkai Zasshi 41(2): 120-127
2006
ISSN/ISBN: 1341-8963 PMID: 16734279 Document Number: 596673
In this study, it was investigated whether previous hepatitis B virus (HBV) infection might be associated with carcinogenesis of hepatocellular carcinoma (HCC) with alcoholic liver disease (ALD).(Method) We compared two HCC groups with ALD, one with previous HBV infection and the other without. In addition, ALD with HCC and without were compared.(Results) The two HCC groups did not differ in terms of age, sex, liver function and liver histology. About 90% of both HCC groups had septal fibrosis or liver cirrhosis. Regarding the comparison of ALD with and without HCC, age and cumulative alcohol were significantly higher in ALD with HCC. The frequency of HBc antibody tended to be higher in ALD with HCC, but the difference was not significant.(Conclusion) There was no difference in HCC with ALD between with and without previous HBV infection. In ALD with severe fibrosis, old age and heavy cumulative alcohol intake, it was important to be on the lookout for the occurrence of HCC.