Study of cellular electrophysiology based on Noble98 dynamic model of ventricular action potential
Zhang, H.; Yang, L.; Jin, Y.; Zhang, Z.; Huang, Y.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 23(1): 6-10
2006
ISSN/ISBN: 1001-5515 PMID: 16532798 Document Number: 596525
On the basis of mammalian ventricular action potential model Noble98, and with the use of Runge-Kutta for solution, the Wenckebach periodicity phenomenon, the transmural heterogeneity of the ventricular myocardium and its rate dependence are studied. The results indicate that these inherent properties may, lead to temporal-space disorganized in the normal heart,and may become the underlying factors for arrhythmias. At the same time, in this study are established the basic methods for quantitative cellular electrophysiology which is essential for future studies on the mechanism of arrhythmia.