Subjective improvement in patients with psoriatic arthritis after short-term oral treatment with seal oil. A pilot study with double blind comparison to soy oil
Madland, T.Magne.; Björkkjaer, T.; Brunborg, L.Anne.; Fröyland, L.; Berstad, A.; Brun, J.G.
Journal of Rheumatology 33(2): 307-310
2006
ISSN/ISBN: 0315-162X PMID: 16465662 Document Number: 596173
Objective: To investigate effects of short-term oral treatment with seal oil in patients with psoriatic arthritis (PsA). Methods: 43 patients with polyarticular PsA were randomized to receive oral treatment for 2 weeks with either seal oil or soya oil in a double blind controlled trial. Clinical and biochemical variables were assessed at baseline, after treatment, and 4 weeks posttreatment. Patients were allowed to continue nonsteroidal antiinflammatory drugs (NSAID) and disease modifying antirheumatic drugs (DMARD) during the study. Results: 40 patients completed the study, 20 in each treatment group. Patients in the seal oil group reported a significant improvement in global assessment of the disease 4 weeks posttreatment (p<0.01), and both groups showed a trend toward improvement in tender joint count, but the differences between the groups were not significant. There was a fall in the ratio of n-6 to n-3 fatty acids and in arachidonic acid (AA) to eicosapentaenoic acid (EPA) in serum after treatment with seal oil (p<0.01). 21% of all patients had elevated values of calprotectin in faeces suggestive of asymptomatic colitis. Conclusion: Treatment with seal oil was followed by a modest improvement in patient's global assessment of the disease and a trend towards a decrease in number of tender joints. There was a shift in fatty acid composition in serum toward a putative antiinflammatory profile. Oral treatment with seal oil may have NSAID-like effects in PsA.