Extensive myelofibrosis responsive to treatment for acute erythroblastic leukaemia
Fadilah, S.-A.-W.; Raja-Zahratul-Azma, R.-S.; Leong, C.-F.
Malaysian Journal of Pathology 28(1): 55-58
2006
ISSN/ISBN: 0126-8635 PMID: 17694960 Document Number: 595709
Intense myelofibrosis is rarely associated with de novo acute myeloid leukaemia (AML) except in acute megakaryoblastic leukaemia (AML-M7) where there is diffuse marrow fibrosis as a consequence of proliferation of neoplastic myeloid cells. AML associated with significant myelofibrosis developing both de novo or secondary to primary (idiopathic) myelofibrosis is characterised by a fulminant course and extremely poor prognosis, primarily due to treatment-resistant disease. The prognostic value of degree of marrow fibrosis in de novo AML has been poorly investigated. We describe a case of extensive myelofibrosis associated with acute erythroblastic leukaemia (AML-M6) that responded to induction therapy of the leukaemia.