Hemolytic anaemia due to unstable hemoglobin arising from spontaneous mutation--a case report
Dash, S.; Menon, S.; Marwaha, R.K.
Indian Journal of Pathology and Microbiology 49(2): 269-270
2006
ISSN/ISBN: 0377-4929 PMID: 16933736 Document Number: 595306
9 years old male child presented clinically with thalassaemia intermedia phenotype. Investigations revealed hemolytic anaemia due to an unstable hemoglobin. Parents were found negative for the abnormal hemoglobin, suggesting a spontaneous mutation in the child. This is the third case of unstable hemoglobin to be reported from India. Clinically it is important that unstable hemoglobin should be suspected in a patient with thalassaemia intermedia phenotype even if both parents are haematologically normal.