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Topical microbicides: the time has come

Dhawan, D.; Keller, M.; Klotman, M.E.

Aids Reader 16(3) 144-148; 155-158 161; Discussion 148: 156-157

2006

ISSN/ISBN: 1053-0894
PMID: 16538955
Document Number: 595165
Microbicides are vaginally or rectally applied drugs that inhibit HIV and other sexually transmitted pathogens. About 30 microbicidal products are being studied in preclinical and clinical trials. Data from in vitro, animal, and in vivo investigations with candidate microbicidal compounds support a proof of concept, although large-scale clinical trials will determine efficacy. Because there are multiple targets for HIV infection in the genital tract, synergistic combinations of microbicides will probably offer the greatest protection for non-HIV-infected persons and might decrease transmissibility when used by those infected with HIV.

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