Clinical research with topical microbicides as a potential HIV prevention method
Van Damme, L.
Aids Reader 10(9): 552-554
2000
ISSN/ISBN: 1053-0894 PMID: 11019454 Document Number: 521846
An overview of the different phases in microbicide research is given with special attention to nonoxynol-9, the only ingredient that has been tested in phase III trials so far. The methodological and ethical challenges in conducting phase III studies are described. These include study population, compliance data, standardization, therapy for HIV-positive women, and informed consent. Despite these challenges, phase III trials are feasible and should be initiated now.