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Effect of glaucocalyxin a on level of Th1/Th2 type cytokines in mice

Chen, Z.-j.; Li, Y.-s.; Zhou, J.-y.; Wang, Z.-t.

Zhongguo Zhong Yao Za Zhi 31(15): 1257-1260

2006

ISSN/ISBN: 1001-5302
PMID: 17048571
Document Number: 595069
To research the effect of glaucocalyxin A (GLA) on the level of Th1/Th2 type cytokines in mice. By using flow cytometer with CBA software to detect Th1/Th2 type cytokines. GLA had insighificant inhibitory effects on Th1 and Th2 cytokines (IL-2, IFN-gamma,TNF-alpha, IL-4 and IL-5) induced by ConA, in which more potential on cytokines from Th1 than those of from Th2 were displayed. However, GLA could produce inhibition on IL-2, IFN-gamma and TNF-alpha and acceleration on IL-4 and IL-5. Immunosuppressive effect of GLA is related to the influence the level of Th1/Th2 type cytokines.

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