Top Abstract Purchase Related
Home
>
Node
>
Subnode

Predictive value of cytokine gene polymorphisms for the development of end-stage renal disease

Babel, N.; Gabdrakhmanova, L.; Hammer, M.H.; Schoenemann, C.; Skrypnikov, V.; Poliak, N.; Volk, H-Dieter.; Reinke, P.

Journal of Nephrology 19(6): 802-807

2006

ISSN/ISBN: 1121-8428
PMID: 17173255
Document Number: 595031
Background: Cytokines play a crucial role in different immunopathological conditions. Cytokine secretion is reported to be determined by polymorphisms in the cytokine genes. Since TNF-alpha and IL-10 are involved in regulation of inflammation, and TGF-beta 1 can induce fibrosis and renal insufficiency - dominant features of end-stage renal disease (ESRD), we explored the hypothesis that polymorphisms of these cytokine genes may be possible genetic susceptibility factors for the progression of renal failure.Methods: We studied the IL-10 (4082), TNF-alpha (-308), TGF-beta 1 (codon 10;25) gene single nucleotide polymorphisms in 118 healthy donors and 103 patients with ESRD (44 hemodialysis patients with diabetic nephropathy and 59 hemodialysis patients with glomerulonephritis) using PCR-SSP.Results: Significant associations of ESRD with the TGF-beta 1 (codon 10) TT (odds ratio [OR] = 5.31; 95% confidence interval [95% CI], 3.77-7.02; p < 0.001) and IL-10 (-1082) GG (OR=2.35; 95% CI, 1.67-3.15; p < 0.01) genotypes were found. Statistical analysis of genotype frequencies made separately for the underlying renal disease (diabetes or glomerulo-nephritis) revealed the same linkage trend: TGF-beta 1 (codon 10) TT and 11,10 (-1082) GG were associated with type 2 diabetic nephropathy (p < 0.001 and p < 0.05, respectively) and chronic glomerulonephritis (p < 0.001 and p < 0.01, respectively). No significant differences in the TNF-alpha, TGF-beta 1 (codon 25) genotype distribution between healthy controls and patients with diabetic nephropathy- or glomerulonephritis-associated ESRD were detected.Conclusions: Carriage of the TGF-beta 1 (codon 10) TT and IL-10 (-1082) GG genotypes may increase susceptibility to ESRD in German patients with type 2 diabetes or glomerulonephritis.

Document emailed within 1 workday
Secure & encrypted payments

Safyan, R.; Whybra, C.; Beck, M.; Elstein, D.; Altarescu, G. 2006: An association study of inflammatory cytokine gene polymorphisms in Fabry disease European Cytokine Network 17(4): 271-275
Moorchung, N.; Srivastava, A.N.; Gupta, N.K.; Ghoshal, U.C.; Achyut, B.R.; Mittal, B. 2007: Cytokine gene polymorphisms and the pathology of chronic gastritis Singapore Medical Journal 48(5): 447-454
Trajkov, D.; Arsov, T.; Petlichkovski, A.; Strezova, A.; Efinska-Mladenovska, O.; Gogusev, J.; Spiroski, M. 2009: Distribution of the 22 cytokine gene polymorphisms in healthy Macedonian population Bratislavske Lekarske Listy 110(1): 7-17
Lo, S.-F.; Huang, C.-M.; Lin, H.-C.; Chen, W.-C.; Tsai, C.-H.; Tsai, F.-J. 2008: Cytokine (IL-6) and chemokine (IL-8) gene polymorphisms among rheumatoid arthritis patients in Taiwan Clinical and Experimental Rheumatology 26(4): 632-637
Spiroska, V.; Kedev, S.; Antov, S.; Trajkov, D.; Petlichkovski, A.; Hristomanova, S.; Djulejic, E.; Paneva, M.; Senev, A.; Spiroski, M. 2009: Association between 22 cytokine gene polymorphisms and dilated cardiomyopathy in Macedonian patients Kardiologia Polska 67(11): 1237-1247
Fellah, H.; Feki, M.; Taieb, S.H.; Hammami, B.; Boubaker, K.; Lacour, B.; Abdallah, T.B.; Kaabachi, N. 2011: Vitamin A, E, B 12 , and Folic Acid in End-Stage Renal Disease Tunisian Patients: Status and Predictive Value for Overall Mortality and Cardiovascular Events Clinical Laboratory 57(11-12): 939-946
Sharples, E.J.; Varagunam, M.; Sinnott, P.J.; McCloskey, D.J.; Raftery, M.J.; Yaqoob, M.M. 2006: The effect of proinflammatory cytokine gene and angiotensin-converting enzyme polymorphisms on erythropoietin requirements in patients on continuous ambulatory peritoneal dialysis Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 26(1): 64-68
Klemm, M.; Eidens, M.; Lorenz, M.; Prause, S.; Weise, A.; Dahmen, N.; Forst, T.; Pf, A.ützner 2010: Development of a High Throughput Single Nucleotide Polymorphism Screening Method for the Cytochrome P450 1A2 Polymorphisms CYP1A2*1C and CYP1A2*1F Are they Useful as Predictive Markers in Mental Disorders? Clinical Laboratory 56(9-10): 473-480
Khadzhieva, M.B.; Kamoeva, S.V.; Ivanova, A.V.; Abilev, S.K.; Salnikova, L.E. 2015: Elastogenesis-Related Gene Polymorphisms and the Risk of Pelvic Organ Prolapse Development Genetika 51(10): 1191-1198
Ludwin, D.; Butler, L.; Arciszewska, M.; Howarth, A.; Singal, D.P. 1989: Matching for HLA-D region and T-cell antigen receptor gene restriction: fragment length polymorphisms in renal transplantation Transplantation Proceedings 21(1 Part 1): 668-670
Brekke, I.B.; Albrechtsen, D.; Flatmark, A. 1988: Renal or combined renal/pancreatic transplantation for diabetic end-stage renal disease? Transplantation Proceedings 20(3): 467-468
Mitz, M.; Di Benedetto, M.; Klingbeil, G.E.; Melvin, J.L.; Piering, W. 1984: Neuropathy in end-stage renal disease secondary to primary renal disease and diabetes Archives of Physical Medicine and Rehabilitation 65(5): 235-238
Zhang, C.; Guo, L. 2015: Interaction of polymorphisms of monocyte chemoattractant protein-1 receptor CCR2 gene 190A/G, nicotinamide adenine dinucleotide phosphate oxidase subunit p22phox gene C242T and cigarette smoking increases the risk of nonalcoholic fatty liver disease Wei Sheng Yan Jiu 44(5): 730-737
Chen, R-Jie.; Zhang, B-Shu.; Wang, S-Min. 2008: Association between estrogen receptor beta gene polymorphisms and Parkinson disease Zhonghua Yi Xue Za Zhi 88(17): 1185-1188
Mendonça, M.I.; Dos Reis, R.P.; Freitas, A.I.; Sousa, A.C.; Pereira, A.; Faria, P.; Gomes, S.; Silva, B.; Santos, N.; Serrão, M.; Ornelas, I.íd.; Freitas, S.ón.; Araújo, J.é J.; Brehm, A.ón.; Cardoso, A.A. 2008: Human paraoxonase gene polymorphisms and coronary artery disease risk Revista Portuguesa de Cardiologia: Orgao Oficial da Sociedade Portuguesa de Cardiologia 27(12): 1539-1555
Salvarani, C.; Boiardi, L.; Casali, B.; Olivieri, I.; Cantini, F.; Salvi, F.; Malatesta, R.; La Corte, R.; Triolo, G.; Ferrante, A.; Filippini, D.; Paolazzi, G.; Sarzi-Puttini, P.; Nicoli, D.; Farnetti, E.; Chen, Q.; Pulsatelli, L. 2004: Vascular endothelial growth factor gene polymorphisms in Behçet's disease Journal of Rheumatology 31(9): 1785-1789
Stefan, P.; Moritz, E.; Alexander, W.; Matthias, W. M.; Norbert, D.; Annette, W.; Thomas, F.; Pfützner Andreas 2009: Development of a High-Throughput Method for Screening the Dopamine D2 (DRD2) Receptor Gene Polymorphisms Based on the LightCycler® System Clinical Laboratory 55(9-10): 353-358
Bennouar, N.; Allami, A.; Laraqui, A.; Azeddoug, H.; El-Kadiri, N.; Benkouka, F.; Bendriss, A.; Ghannam, R.; Benomar, A.; Fellat, S.; Benomar, M. 2004: Apolipoprotein E and angiotensin-converting enzyme gene polymorphisms as risk factors of coronary disease Annales de Biologie Clinique 62(3): 295-304
Woo, P. 2000: Cytokine polymorphisms and inflammation Clinical and Experimental Rheumatology 18(6): 767-771
Pan, J.P.; Chiang, A.N.; Tai, J.J.; Wang, S.P.; Chang, M.S. 1995: Restriction fragment length polymorphisms of apolipoprotein B gene in Chinese population with coronary heart disease Clinical Chemistry 41(3): 424-429