Elastogenesis-Related Gene Polymorphisms and the Risk of Pelvic Organ Prolapse Development
Khadzhieva, M.B.; Kamoeva, S.V.; Ivanova, A.V.; Abilev, S.K.; Salnikova, L.E.
Genetika 51(10): 1191-1198
2015
ISSN/ISBN: 0016-6758 PMID: 27169234 Document Number: 681408
Pelvic organ prolapse (POP) represents a urologic and gynecological disease, the development of which is governed both by environmental and genetic factors. We describe the results of our association study of polymorphic variants of genes involved in the assembly of elastic fibrils, namely, the lysyl oxidase protein 1 (LOXL1) and fibulin-3 (FBLN3) genes. We revealed an association of the rs2304719-T allele and rs2165241 (C)-rs2304719(T)-rs893821(T) haplotype of the LOXL1 gene with an increased risk of POP development, as well as a weak association with the disease of the rs3791660-C allele and the rs3791679(T)- rs1367228(A)-rs3791660(C)-rs2033316(A) haplotype of the FBLN3 gene.