UV spectrophotometric assay of famotidine in combination with picrolonic acid, picrolinate
Apostu, M.; Bibire, N.; Dorneanu, V.
Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 109(2): 422-425
2005
ISSN/ISBN: 0048-7848 PMID: 16607813 Document Number: 594963
Famotidine, belonging to H2-antagonist group, is a compound containing a thiazolic moiety and it is used in peptic ulcer therapy. This paper debates the possibility of developing a new ultraviolet spectrophotometric assessment by using the reaction between famotidine and picrolonic acid. We carried out our determinations at 362 nm, where the absorbency of famotidine - picrolonic acid complex is maximal, and we have established the optimal reaction conditions. This method was successfully applied for famotidine assay from pharmaceutical dosage forms.