Visualization of regenerated sciatic nerve of rat after injury
Chen, J.; Peng, C.; Chu, Y.; Zhu, G.; Li, B.; Zhao, H.; Chen, Z.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 22(2): 324-326
2005
ISSN/ISBN: 1001-5515 PMID: 15884545 Document Number: 594050
There is close relationship between the morphologic changes of peripheral nerve after injury and its function recovery during regeneration. In our experiment, the sciatic nerve of rats was transected and bridge-connected with silicone tube, and the images of serial slices of different time and different injury parts were taken by micro-photograph system. The volume unit model was applied to rendering the three dimensional (3D) structure of degenerative and regenerative sciatic nerve fiber and its affiliated structure after injury. The 3D images showed that node of Ranvier had not formed and its array was turbulent, both the myelin sheath and the axis-cylinder were thinner, and the collagen fibres had proliferated.