NP-detecting DNA technologies: solving problems of applied biochemistry
Krakhmaleva, I.N.; Shishkin, S.S.; Shakhovskaia, N.I.; Stoliarova, E.B.; Plugov, A.G.; Kniazev, A.I.; Khomenkov, V.G.; Shevelev, A.B.; Chernov, N.N.
Prikladnaia Biokhimiia i Mikrobiologiia 41(3): 303-307
2005
ISSN/ISBN: 0555-1099 PMID: 15977791 Document Number: 593477
Heterozygosity of CANP3, ACTN3, and GHR genes in specialized collections was studied using state-of-the-art DNA technologies for DNA analysis. A new dinucleotide deletion (AC) at the beginning of exon 21 was identified in five individuals with heterozygous CANP3 gene. Analysis of polymorphism (SNP1747 C-->T) of ACTN3 gene demonstrated a positive association of allele C with a high muscular performance. Real-time PCR assay of SNP1630 (A-->C) in GHR gene suggested a putative negative association of allele C of this SNP with a high muscular performance.