New method for detecting and quantitating pharmacokinetic drug-drug interactions applied to ethanol-propranolol
Wagner, J.G.; Weidler, D.J.; Lin, Y.J.
Research Communications in Chemical Pathology and Pharmacology 13(1): 9-18
1976
ISSN/ISBN: 0034-5164 PMID: 1257604 Document Number: 104106
A novel method for detecting and quantitating pharmacokinetic drug-drug interactions is described. The method involves perturbation of an existing steady-state whole blood (or plasma) concentration of one drug by the other drug. The method would allow differentiation of "pharmacokinetic" drug interactions from "pharmacologic" interactions. It is shown that a bolus intravenous injection of propranolol reduced a steady-state arterial blood concentration of ethyl alcohol by 26% in the cat.