Disseminated infections due to Scedosporium apiospermum in a patient with anaplastic large cell lymphoma. a case study
Dan, M.; Mereuţă, A.-I.; Burcoveanu, C.
Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 109(3): 638-641
2005
ISSN/ISBN: 0048-7848 PMID: 16607764 Document Number: 592979
A 42-year-old man was diagnosed with hepatosplenic T-cell lymphoma in November 2003. Remission was incompletely achieved despite 10 courses of chemotherapy. He developed fever (38.5-39 degrees C), chills, cough and morning expectoration after the 61 courses of chemotherapy. During this period, an ultrasound of the abdomen showed multiple hypodense lesions of the liver. Culture of the sputum yielded Scedosporium apiospermum. Fungal cultures from blood remained negative. The patient was treated with voriconazol. After one month from therapy, an ultrasound examination showed decreasing of hypodense lesions of the liver, and no further lesions appeared. Based on significant improvement of liver lesions with voriconazole therapy, we proposed the diagnostic "probable" disseminated infections due to S.apiospermum.