The t (2;5) (p23;q35) : a recurring chromosomal abnormality in Ki-1-positive anaplastic large cell lymphoma
Le Beau, M.M.; Bitter, M.A.; Larson, R.A.; Doane, L.A.; Ellis, E.D.; Franklin, W.A.; Rubin, C.M.; Kadin, M.E.; Vardiman, J.W.
Leukemia 3(12): 866-870
1989
ISSN/ISBN: 0887-6924 PMID: 2555633 Document Number: 344437
In lymphoid neoplasms, nonrandom cytogenetic abnormalities correlate with clinical, morphologic and immunophenotypic features. A subtype of non-Hodgkin's lymphoma, which expresses the Ki-1 antigen (CD30) and has distinct morphologic and clinical features, has recently been described. We now report the association of a reciprocal translocation involving the short arm of chromosome 2 (band p23) and the long arm of chromosome 5 (band q35), t(2;5)(p23;q35), with Ki-1 positive anaplastic large cell lymphoma. Rearrangement of the genes that are located at the breakpoints on chromosomes 2 and 5 may be a critical step in the pathogenesis of this lymphoma.