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Localized hand-foot syndrome after intra-arterial hepatic chemotherapy with floxuridine: a clinical case

Bareggi, C.; Paleari, D.; Garassino, M.Chiara.; Mora, M.; Salamina, S.; Senecione, M.; Ghidini, A.; Pancera, G.

Tumori 91(2): 193-196

2005

ISSN/ISBN: 0300-8916
PMID: 15948551
Document Number: 592876
Hand-foot syndrome is a toxic effect of some chemotherapy agents such as 5-fluorouracil (5-FU), capecitabine and liposomal doxorubicin. The symptoms and signs are localized erythema and paresthesia. Floxuridine (FUDR) is an analogue of 5-FU, used for arterial hepatic infusion in patients affected by liver metastases from colorectal cancer. A patient who was treated for colorectal cancer with liver metastases underwent locoregional chemotherapy with FUDR and systemic chemotherapy with FOLFOX4. After three cycles he developed severe painful dermatitis of the right leg. Abdominal X-ray showed displacement of the catheter to the right common iliac artery. Treatment was discontinued and the patient had a rapid recovery.

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