Clinical analysis of bladder cancer patients undergoing radical cystectomy
Kato, Y.; Hasegawa, Y.; Wakita, T.; Hayashi, N.
Hinyokika Kiyo. Acta Urologica Japonica 51(11): 719-725
2005
ISSN/ISBN: 0018-1994 PMID: 16363702 Document Number: 590513
A retrospective clinicopathological study Was performed on 96 bladder cancer patients who underwent radical cystectomy and pelvic lymphadenectomy at Aichi Cancer Center between April 1994 and July 2004. The follow-up period ranged from 4 to 109 months, With a mean of 39.1 months. The overall cancer-specific survival rates at 3, 5 and 7 years Were 81.7%, 71.2% and 71.2%, respectively. The 5-year survival rate according to pathological stage Was 97.3% for pT1 or lower, 66.4% for pT2, 47.6% for pT3, and 25.4% for pT4. Univariate analysis demonstrated the prognostic significance of pathological stage (p<0.001), lymph node metastasis (p=0.001), venous invasion (p<0.001), lymphatic invasion (p=0.010), preoperative creatinine clearance (p=0.001) and preoperative hydronephrosis (p<0.001). Multivariate analysis revealed strong independent correlations of venous invasion (p=0.040) and preoperative hydronephrosis (p=0.016) with prognosis.