Prostaglandin E1 transport into rat intestinal cryptic cell line IEC-6
Hirata, K.; Mabashi, K.; Horie, T.
Research Communications in Molecular Pathology and Pharmacology 117-118: 115-124
2005
ISSN/ISBN: 1078-0297 PMID: 18426083 Document Number: 590458
Administration of antitumor drugs such as 5-fluorouracil and methotrexate to rats causes intestinal injury. The intestinal injury was reported to be prevented by coadministration of prostaglandin E1 analogues to rats. IEC-6 cell is a useful in vitro model to study the cytoprotective effect in enterocytes, For its purpose, it is important to know whether or not prostaglandins are taken up into IEC-6 cells. The transport of prostaglandin E1 into IEC-6 cells was investigated, using [3H]-prostaglandin E1. Prostaglandin E1 was found to be transported into IEC-6 cells by the passive diffusion mechanism.