Excitatory effect of low dose of manganese on spontaneous discharges of dorsal root ganglion neurons
Yang, R.-H.; Chen, J.-Y.; Hu, S.-J.
Wei Sheng Yan Jiu 34(4): 397-399
2005
ISSN/ISBN: 1000-8020 PMID: 16229256 Document Number: 590342
To investigate the toxicity of low dose of manganese on peripheral nervous system. With methods of the perfusion of dorsal root ganglion (DRG) in vitro and single fiber recording of the spontaneous discharges, the effect of manganese chloride (MnCl2 1, 2, 5, 10, 50, 100 micromol/L) on neurons were observed. MnCl2 enhanced spontaneous discharges of DRG neurons in dose-dependent manner, but failed to affect the discharges of silent fibers. Different patterns of effects were observed in study. 1 micromol/L MnCl2 persistent enhanced the spontaneous discharges. The frequency of discharges reversed after a transient excitatory effect when 5 micromol/L MnCl2 was applied. However, 50 micromol/L MnCl2 gradually decreased the frequency of discharges followed a transient excitatory effect. These results suggest that low dose of manganese enhanced the spontaneous discharges of DRG neurons. This may partially explain the mechanism of paraesthesia in slight poison of manganese.