Inhibition of mexiletine on sodium current in dorsal root ganglion neurons of rats
Zhang, X.F.; Wang, T.Y.; Zhang, L.
Zhongguo Yao Li Xue Bao 15(2): 186-188
1994
ISSN/ISBN: 0253-9756 PMID: 8010119 Document Number: 425270
Using whole-cell configuration of patch clamp technique we found that mexiletine (Mex) reversibly inhibited the sodium current in a voltage- and use-dependent manner in cultured dorsal root ganglion (DRG) neurons. The threshold concentration of Mex was 5 mu-mol cntdot L-1. The inhibitory action heightened with increasing concentrations of Mex. Complete inhibition was achieved at 150 mu-mol cntdot L-1 and the 50% inhibition concentration was 31 mu-mol cntdot L-1. It is suggested that the inhibition of Mex on sodium current in neurons may be one of the mechanisms of its anti-ischemic and anti-anoxic effects on the neuron.