Aminoguanidin improves learning process in neonatal rats exposed to hypoxia-ischemia
Khurtsia, M.; Zananian, I.; Pavlenishvili, I.; Bekaia, G.
Georgian Medical News 121: 81-86
2005
ISSN/ISBN: 1512-0112 PMID: 15908734 Document Number: 589694
Seven-day-old rats (n = 40) were divided into five groups (8 pups in each of them). They were exposed to unilateral common carotid artery ligation, 2-3 h later followed by 2,5 h hypoxia (8% oxygen in 92% nitrogen) at 37 degrees C and immediately after insult once a day during three days received i/p injection of aminoguanidin (150 mg/kg) (group 1). Group 2 underwent procedures similar to the first group but received i/p injection of 300 mg/kg aminoguanidin. Group 3 instead of aminoguanidin received the same amount of saline. Group 4 composed by false-operated pups and Group 5--by intact pups. 22 days after hypoxic-ischemic exposure pups underwent 12 day learning test in multi-way maze. Process of learning in hypoxia-ischemic pups (group 3) were essentially deteriorated in comparison with false-operated and intact pups, but in groups were animals received aminoguanidin process of learning was close to control rats.