Microsatellite instability and p53 mutations are characteristic of subgroups of acute myeloid leukemia but independent events
Herzog, G.; Lu-Hesselmann, J.; Zimmermann, Y.; Haferlach, T.; Hiddemann, W.; Dreyling, M.
Haematologica 90(5): 693-695
2005
ISSN/ISBN: 0390-6078 PMID: 15921389 Document Number: 589069
Microsatellite instability (MSI) and p53 alterations which may represent major mechanisms of genetic instability, are rarely observed in de novo acute myeloid leukemia (AML) but may play a substantial role in subgroups characterized by either a myelodysplastic prephase (sAML), previous chemotherapy (tAML) or a complex aberrant karyotype. We performed allelotyping and p53 mutation analysis in 75 patients with morphologically and cytogenetically classified AML.
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