Extensive chronic graft-versus-host disease of skin successfully treated with thalidomide
Nair, V.; Sharma, A.; Ghosh, I.; Arora, S.; Sahai, K.; Dutta, V.
Journal of the Association of Physicians of India 53: 988-990
2005
ISSN/ISBN: 0004-5772 PMID: 16515241 Document Number: 588396
Thirty years female underwent allogenic peripheral blood stem cell transplantation for chronic myeloid leukaemia--chronic phase. She developed grade II acute skin graft-versus-host disease (GVHD) which was treated with cyclosporine and a short course of steroids. She developed extensive chronic GVHD of the skin and liver three hundred days post-transplant. She was managed with the standard immunosuppressants with partial response of liver dysfunction but no response of skin lesions. She showed a good response to therapy with resolution of skin lesions after treatment with thalidomide.