Overexpression of sterol carrier protein-2 mRNA in patients with cholesterol gallstones
Cui, N.-Q.; Zhang, S.-K.; Cui, Y.-F.; Li, D.-H.; Chen, C.; Wu, X.-Z.
Hepatobiliary and Pancreatic Diseases International Hbpd Int 4(1): 117-120
2005
ISSN/ISBN: 1499-3872 PMID: 15730934 Document Number: 587879
Hypersecretion of biliary cholesterol is believed to be one of the important causes of lithogenic bile. Sterol carrier protein-2(SCP2) participates in cholesterol trafficking and metabolism and may play a key role in cholesterol gallstone formation. This study was undertaken to investigate the expression of liver SCP2 mRNA in patients with cholesterol gallstone and those patients with non-cholesterol gallstone. The expression of liver SCP2mRNA was studied in 36 patients with cholesterol gallstone and 30 patients with non-cholesterol gallstone by reverse transcription-polymerase chain reaction (RT-PCR). The expression of SCP2 mRNA was increased more significantly in patients with cholesterol gallstone than in patients with non-cholesterol gallstone. The SCP2 gene was overexpressed in patients with cholesterol gallstone, indicating that SCP2 may be one of the important causes of cholesterol gallstone.