Genomic imprinting and human pathology
Polívková, Z.
Casopis Lekaru Ceskych 144(4) 245-250; Discussion: 250-251
2005
ISSN/ISBN: 0008-7335 PMID: 15945483 Document Number: 587864
Genomic imprinting is an epigenetic form of regulation of gene expression. Imprinted genes are transcribed from one allele of specific parental origin. Such genes are normally involved in embryonic growth and behavioral development. Deregulation of imprinted genes has been observed in a number of human diseases as gestation trophoblastic disease, Prader-Willi, Angelmann and Beckwith-Wiedemann syndromes and plays significant role in the carcinogenesis. Review of recent knowledge on mechanism and regulation of imprinting is presented in this paper.