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Cobra snake venom reduces significantly tissue nucleic acid levels in human breast cancer

Jokhio, R.; Ansari, A.Farooq.

Jpma. Journal of the Pakistan Medical Association 55(2): 71-73

2005

ISSN/ISBN: 0030-9982
PMID: 15813633
Document Number: 587680
Objective: To look into the feasibility of using cobra snake venom in suppressing breast cancer tissue through inhibition of nucleic acid synthesisMethods: Samples of breast cancerous tissue, obtained from Atomic Energy Medical Center, LMCH, Jamshoro, incubated with varying concentrations of venom and without venom (as controls) were assayed for macromolecular (RNA and DNA) levelsResults: No. change in the control samples while a prominent and significant fall in nucleic acid contents has been noted in venom treated tissues. Also, maximum effect was observed with 25ug/ml dose.Conclusion: Snake venom strongly inhibited the formation of nucleic acids in the breast cancerous tissues. It may bring a fall in cell proliferation, thus there is hope that venom could be used as an anti-cancerous drug in the future.

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