The role of morphological characteristics of lymph nodes in differential diagnosis of reactive lymphadenopathies
Melikian, A.L.; Kaplanskaia, I.B.; Nikitin, E.A.; Kovaleva, L.G.
Terapevticheskii Arkhiv 77(4): 37-43
2005
ISSN/ISBN: 0040-3660 PMID: 15938531 Document Number: 586716
Aim. To analyse causes of reactive lymphadenitis regarding histological changes in the lymph node, of diagnostic errors; to determine frequency of establishment of nosological diagnosis.Material and methods. A retrospective analysis of diagnostic examination of 375 patients with reactive lymphadenitis observed from 1992 to 2000 was made.Results. For differential diagnosis 6 groups of reactive lymphadenopathies with different histological picture were identified: follicular hyperplasia, paracortical hyperplasia, granulomatous lymphadenitis, granulomatous pyonecrotic lymphadenitis, sinus histiocytosis as a leading sign and node necrosis as a leading sign. The analysis of making nosological diagnosis for each group and of diagnostic errors was conducted.Conclusion. Characteristics of lymph node changes in reactive lymphadenitis is of great importance. Better cooperation between histologists and clinicians must improve efficacy of reactive lymphadenitis diagnosis.