Research of the hemostasis effect of chitosan acetic acid solution
Tian, F.; Yang, J.; Chen, S.; Kan, Y.; Ji, F.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 22(5): 999-1003
2005
ISSN/ISBN: 1001-5515 PMID: 16294739 Document Number: 586592
The effect of chitosan with different molecular weight and deacetylation degree on blood hemostasis was tested. The experiments found evident alteration of red blood cell morphology and unusual coagglutination between erythrocytes in the anticoagulant blood which was treated by chitosan acetic acid solution. The red blood cells clot formation experiments showed that chitosan with low deacetylation degree (60%-70%) caused more red blood cells to assemble when compared versus chitosan with other deacetylation degrees. The effect of molecular weight between 10(5)-10(6) was not obvious. The thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), and concentration of fibrinogen (FIB) of blood treated by chitosan acetic acid solution were measured. The results proved that the hemostasis property of chitosan acetic acid solution was independent of the platelets and the normal "Cascade-like" coagulation pathway.