Applications of microwave-assisted organic synthesis on the multigram scale
Wolkenberg, S.E.; Shipe, W.D.; Lindsley, C.W.; Guare, J.P.; Pawluczyk, J.M.
Current Opinion in Drug Discovery and Development 8(6): 701-708
2005
ISSN/ISBN: 1367-6733 PMID: 16312146 Document Number: 586584
This review presents a summary of reactions performed using microwave irradiation on a multigram scale. Results are described in the context of existing equipment, and equipment currently in development, for the processing of multigram to kilogram quantities of materials including single- and multimode microwave reactors and batch, batch-flow and continuous-flow systems. Although limited in number, reports found in the literature to date suggest that with appropriate controls, reproducible scale-up of microwave reactions is feasible and requires minimal re-optimization of laboratory-scale reaction conditions. This feature, along with the dramatic reductions in reaction time generally observed for microwave reactions suggests that application of this technology in process research could be beneficial.