After your heart arrest, would you like to test a medicinal elixir?

Carron, P.-N.; Hugli, O.; Liaudet, L.; Yersin, B.

Revue Medicale Suisse 1(6): 448-451

2005


ISSN/ISBN: 1660-9379
PMID: 15786650
Document Number: 586406
So far, cardiac arrest is still associated with high mortality or severe neurological disability in survivors. At the tissue level, cardiac arrest results into an acute condition of generalized hypoxia. A better understanding of the pathophysiology of ischemia-reperfusion and of the inflammatory response that develops after cardiac arrest could help to design novel therapeutic strategies in the future. It seems unlikely that a single drug, acting as a <>, might be able to improve survival or neurological prognosis. Lessons learned from pathophysiological mechanisms rather indicate that combined therapies, involving thrombolysis, neuroprotective agents, antioxidants and anti-inflammatory molecules, together with temperature cooling, might represent helpful strategies to improve patient's outcome after cardiac arrest.

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