Implementation of the radiolabelled antibiotic in the detection of orthopedic infections
Obradović, V.; Artiko, V.; Davidović, B.; Vucetić, C.; Lesić, A.; Sudjić, V.; Nikolić, N.; Marinković, V.; Petrović, N.; Bosnjaković, V.
Glas. Srpska Akademija Nauka i Umetnosti. Odeljenje Medicinskih Nauka 48: 91-100
2005
ISSN/ISBN: 0371-4039 PMID: 16405233 Document Number: 585808
The aim of the study is detection and evaluation of the orthopedic infections using 99mTc-ciprofloxacin, radiopharmaceutical supposed to distinguish inflammation from infection. There were 15 true positive findings, 9 true negative, and two were false positive, while 1 was false negative. Sensitivity was 94%, specificity 82%, positive predictive value 88%, negative predictive value 90% and accuracy 89%. According to our results, scintigraphy with 99mTc-ciprofloxacin is a useful method for detection and assessment of exact localization of orthopedic infections, which might be useful for (differential) diagnosis, surgical treatment in due time as well as monitoring of the treatment of conservative therapy.