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Effect of natural tachykinins on the bile production in rats

Spivak, L.S.; Makarchuk, M.I.; Liashchenko, T.P.; Vesel's'kyĭ, S.P.

Fiziolohichnyi Zhurnal 51(4): 61-64

2005

ISSN/ISBN: 2522-9028
PMID: 16201152
Document Number: 585765
We studied the changes of biligenesis and bile chemical composition under the influence of endogenous mammalian tachykinins in the acute experiments on the rats with biliary duct cannulated. We have shown that substance P, neurokinin A and neurokinin B changed volume of bile secretion and this liver reaction was accompanied by the essential changes of the bile chemical composition. Above mentioned peptides strengthen solubilisation abilities of the bile that diminishes its lithogenicity. The later is an important factor in the medical treatment of functional disturbances of the hepatobiliary system.

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