The combined therapy of carcinoma of the tongue by using bleomycin and radiation
Tepmongkol, P.; Nilprabhassorn, P.; Suvanasuthi, R.; Srichomkwan, A.
Journal of the Medical Association of Thailand 57(4): 186-190
1974
ISSN/ISBN: 0125-2208 PMID: 4142795 Document Number: 5849
The biological effect of bleomycin resembles that, of X-ray irradiation indicating that the combination of bleomycin and radiotherapy may have a synergistic effect. Ten patients with T3 or T4 and No to N3 (U1CC) were treated with bleomycin 150 mg and then followed by radiation compared with 10 patients with the same tumour extent randomized numerically, receiving radiation alone. The result of combined therapy showed 9 from 10 patients' or 90 per cent effective on the basis of objective primary tumour response and 5 from 6 patients or 80 per cent on secondary tumour response which were definitely superior to radiation alone. The combined therapy did not improve the survival time. No drug morbidities due to drug toxicity were found. There was no pulmonary complication and not a single case of bone marrow depression was observed.
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