Current understanding of primary biliary cirrhosis
Il'ichenko, L.Iu.; Golovanova, E.V.; Tsaregorodtseva, T.M.; Serova, T.I.; Gudkova, R.B.
Terapevticheskii Arkhiv 77(2): 50-54
2005
ISSN/ISBN: 0040-3660 PMID: 15807453 Document Number: 584683
Aim. To examine characteristics of the course of primary biliary cirrhosis (PBC).Material and methods. The study of 150 PBC patients aged 26-82 years used clinical, biochemical, immunological and morphological methods.Results. Antimitochondrial antibodies of type M2 (AMAM2) were detected in 85.4% patients with PBC. A positive correlation was found between clinicobiochemical activity of the disease and number of AMAM2. AMAM2-positive patients more frequently had extrahepatic manifestations, overlap syndrome, higher biochemical and immunological activity vs AMAM2-negative patients.Conclusion. The following variants of PBC course were identified: classic AMAM2-positive, AMAM2-negative, overlapping of PBC and autoimmune hepatitis. Concentration of AMAM2 has diagnostic and prognostic value in PBC.