The influence of relative humidity and temperature on stability of moexipril hydrochloride in solid phase
Stanisz, B.
Acta Poloniae Pharmaceutica 61(2): 91-96
2004
ISSN/ISBN: 0001-6837 PMID: 15493289 Document Number: 583964
Kinetic and thermodynamic parameters of the decomposition of moexipril hydrochloride in solid phase in the absence and presence of humidity were calculated. The evaluation of stability of moexipril hydrochloride was followed by the HPLC method. The applied method was validated (evaluation of the following parameters: selectivity, linearity, precision, limit of detection (LOD), limit of quantification (LOQ) and repeatability). The effect of humidity on the stability of MHCl in solid phase at 363 K was described by the equation: In ki = ax + b = (0.0676 +/- 0.016) . RH% - (15.53+/-0.78). Identification of degradation products of MHCl were carried out by the HPLC-MS method.