Effects of epidermal growth factor on calciumion and cAMP in the ductal cells of submandibular glands
Huang, S.-h.; Kou, Y.-r.; Tan, X.-x.; Zhou, Q.; Deng, C.-f.; Wang, Y.-x.
Shanghai Kou Qiang Yi Xue 13(1): 56-58
2004
ISSN/ISBN: 1006-7248 PMID: 15007484 Document Number: 583589
To study the effects of EGF on Ca(2+) and cAMP in the ductal cells of rat SMG. Fluorometric technique and radioimmunological technique were used to investigate the dynamic changes of Ca(2+) and cAMP in the ductal cells. The data were analysed statistically by t test. After an momently latent period, intercellular calcium increased rapidly, then began to decline. This period could last 5 minutes. After 3 minutes, cAMP showed a rapid decrease, and then increased slowly. Its concentration could restore 90 minutes later. EGF may regulate intercellular calcium and cAMP, which results in the proliferation of the ductal cells.